Innovative regenerative therapy approach: L-PRF

Speaker: David M. Dohan Ehrenfest

Originally broadcasted on: 17th November, 2014, 6:00 PM CEST Other time zones

Among the many technologies developed to improve our current therapeutic strategies in periodontology and implant dentistry, the use of biomaterials promoting tissue regeneration is an important path of research.


Platelet concentrates for surgical use, often called PRP (Platelet-Rich Plasma) were widely tested since 1998, with the hope to improve healing through the release of platelet growth factors. However, these PRPs offered mixed clinical results, and their use remains scarse and controversial in oral and maxillofacial applications. On the contrary, the use of another family called Leukocyte- and Platelet-Rich Fibrin (L-PRF) is now developing very quickly, as this material is easy to use, very useful and efficient in most oral surgery situations, easy to prepare and inexpensive. L-PRF is a strong fibrin-based membrane rich in growth factors and healing cells. In this lecture, we will develop the basic knowledge about PRP and PRF, explain their differences and particularities, and illustrate the many clinical opportunities offered by the use of L-PRF in periodontal surgeries and implant-supported rehabilitations.

Learning objectives:

Prof. David M. Dohan Ehrenfest will present the biological background and mechanisms of action as well as the specific protocol of the L-PRF technique, from blood drawing to the final L-PRF matrix.


David M. Dohan Ehrenfest
David M. Dohan EhrenfestProf. David M. Dohan Ehrenfest is currently the Director of the LoB5 unit, Research Center for Biomineralization Disorders, Chonnam National University School of Dentistry, South Korea. After his studies in Paris University (DDS, MS, PhD and Habilitation), he worked at the University of Paris, France, the University of Gothenburg, Sweden and the University Federico 2 of Naples, Italy.

He is the author of more than 200 articles (national or international) in the fields of periodontology and implant dentistry, and the Editor-in-chief of the international POSEIDO Journal (Periodontology, Oral Surgery, Esthetic & Implant Dentistry Open, His centers of interest are particularly the various applications of platelet concentrates (platelet-rich fibrin PRF, platelet-rich plasma PRP), and the development of new implant surfaces, design and bone materials.

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